| First Author | Ko R | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 6765 | PubMed ID | 25828701 |
| Mgi Jnum | J:222744 | Mgi Id | MGI:5645449 |
| Doi | 10.1038/ncomms7765 | Citation | Ko R, et al. (2015) Glycogen synthase kinase 3beta ubiquitination by TRAF6 regulates TLR3-mediated pro-inflammatory cytokine production. Nat Commun 6:6765 |
| abstractText | TRAF6 is critical for the production of inflammatory cytokines in various TLR-mediated signalling pathways. However, it is poorly understood how TRAF6 regulates TLR3 responses. Here we demonstrate that GSK3beta interacts with TRAF6 and positively regulates the TLR3-mediated signalling. Suppression of GSK3beta expression or its kinase activity drastically reduces the production of inflammatory cytokines and the induction of c-Fos by decreasing ERK and p38 phosphorylation. GSK3beta physically associates with TRAF6 in a TLR3 ligand poly I:C-dependent manner. TRAF6 is determined to be a direct E3 ligase for GSK3beta, and TRAF6-mediated GSK3beta ubiquitination is essential for poly I:C-dependent cytokine production by promoting the TLR3 adaptor protein TRIF-assembled signalling complex. |
