| First Author | Yu EA | Year | 2011 |
| Journal | Aging (Albany NY) | Volume | 3 |
| Issue | 5 | Pages | 479-93 |
| PubMed ID | 21566258 | Mgi Jnum | J:224281 |
| Mgi Id | MGI:5661811 | Doi | 10.18632/aging.100323 |
| Citation | Yu EA, et al. (2011) Disrupting the circadian clock: gene-specific effects on aging, cancer, and other phenotypes. Aging (Albany NY) 3(5):479-93 |
| abstractText | The circadian clock imparts 24-hour rhythmicity on gene expression and cellular physiology in virtually all cells. Disruption of the genes necessary for the circadian clock to function has diverse effects, including aging-related phenotypes. Some circadian clock genes have been described as tumor suppressors, while other genes have less clear functions in aging and cancer. In this Review, we highlight a recent study [Dubrovsky et al., Aging 2: 936-944, 2010] and discuss the much larger field examining the relationship between circadian clock genes, circadian rhythmicity, aging-related phenotypes, and cancer. |
