First Author | Toker A | Year | 2015 |
Journal | Cancer Cell | Volume | 28 |
Issue | 2 | Pages | 143-5 |
PubMed ID | 26267528 | Mgi Jnum | J:224917 |
Mgi Id | MGI:5689751 | Doi | 10.1016/j.ccell.2015.07.010 |
Citation | Toker A, et al. (2015) PIPPing on AKT1: How Many Phosphatases Does It Take to Turn off PI3K?. Cancer Cell 28(2):143-5 |
abstractText | In this issue of Cancer Cell, Ooms and colleagues show that the lipid phosphatase PIPP/INPP5J, frequently inactivated in triple-negative breast cancers, functions as a tumor suppressor by specifically modulating the activity of AKT1 in the context of oncogenic PI3K signaling, leading to inhibition of metastatic dissemination. |