| First Author | Swamy M | Year | 2015 |
| Journal | Nat Commun | Volume | 6 |
| Pages | 7090 | PubMed ID | 25987506 |
| Mgi Jnum | J:224929 | Mgi Id | MGI:5689763 |
| Doi | 10.1038/ncomms8090 | Citation | Swamy M, et al. (2015) Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance. Nat Commun 6:7090 |
| abstractText | Unrelenting environmental challenges to the gut epithelium place particular demands on the local immune system. In this context, intestinal intraepithelial lymphocytes (IEL) compose a large, highly conserved T cell compartment, hypothesized to provide a first line of defence via cytolysis of dysregulated intestinal epithelial cells (IEC) and cytokine-mediated re-growth of healthy IEC. Here we show that one of the most conspicuous impacts of activated IEL on IEC is the functional upregulation of antiviral interferon (IFN)-responsive genes, mediated by the collective actions of IFNs with other cytokines. Indeed, IEL activation in vivo rapidly provoked type I/III IFN receptor-dependent upregulation of IFN-responsive genes in the villus epithelium. Consistent with this, activated IEL mediators protected cells against virus infection in vitro, and pre-activation of IEL in vivo profoundly limited norovirus infection. Hence, intraepithelial T cell activation offers an overt means to promote the innate antiviral potential of the intestinal epithelium. |
