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Publication : Atrial natriuretic peptide in cardiovascular biology and disease (NPPA).

First Author  Song W Year  2015
Journal  Gene Volume  569
Issue  1 Pages  1-6
PubMed ID  26074089 Mgi Jnum  J:225744
Mgi Id  MGI:5694298 Doi  10.1016/j.gene.2015.06.029
Citation  Song W, et al. (2015) Atrial natriuretic peptide in cardiovascular biology and disease (NPPA). Gene 569(1):1-6
abstractText  Atrial natriuretic peptide (ANP) is a cardiac hormone that regulates salt-water balance and blood pressure by promoting renal sodium and water excretion and stimulating vasodilation. ANP also has an anti-hypertrophic function in the heart, which is independent of its systemic blood pressure-lowering effect. In mice, ANP deficiency causes salt-sensitive hypertension and cardiac hypertrophy. Recent studies have shown that ANP plays an important role in regulating vascular remodeling and energy metabolism. Variants in the human NPPA gene, encoding the ANP precursor, are associated with hypertension, stroke, coronary artery disease, heart failure (HF) and obesity. ANP and related peptides are used as biomarkers for heart disease. Recombinant proteins and small molecules that enhance the ANP pathway have been developed to treat patients with HF. In this review, we discuss the role of ANP in cardiovascular biology and disease.
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