| First Author | Ellison TS | Year | 2015 |
| Journal | Dis Model Mech | Volume | 8 |
| Issue | 9 | Pages | 1105-19 |
| PubMed ID | 26159543 | Mgi Jnum | J:225910 |
| Mgi Id | MGI:5694897 | Doi | 10.1242/dmm.019927 |
| Citation | Ellison TS, et al. (2015) Suppression of beta3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis. Dis Model Mech 8(9):1105-19 |
| abstractText | Anti-angiogenic treatments against alphavbeta3-integrin fail to block tumour growth in the long term, which suggests that the tumour vasculature escapes from angiogenesis inhibition through alphavbeta3-integrin-independent mechanisms. Here, we show that suppression of beta3-integrin in mice leads to the activation of a neuropilin-1 (NRP1)-dependent cell migration pathway in endothelial cells via a mechanism that depends on NRP1's mobilisation away from mature focal adhesions following VEGF-stimulation. The simultaneous genetic targeting of both molecules significantly impairs paxillin-1 activation and focal adhesion remodelling in endothelial cells, and therefore inhibits tumour angiogenesis and the growth of already established tumours. These findings provide a firm foundation for testing drugs against these molecules in combination to treat patients with advanced cancers. |
