| First Author | Castell A | Year | 2015 |
| Journal | Cancer Discov | Volume | 5 |
| Issue | 7 | Pages | 701-3 |
| PubMed ID | 26152922 | Mgi Jnum | J:227233 |
| Mgi Id | MGI:5699946 | Doi | 10.1158/2159-8290.CD-15-0660 |
| Citation | Castell A, et al. (2015) Targeting MYC Translation in Colorectal Cancer. Cancer Discov 5(7):701-3 |
| abstractText | There is a great interest in finding ways to inhibit the expression or activity of the "undruggable" MYC, a master regulator of transcription and one of the most deadly oncoproteins in human cancer. In this issue of Cancer Discovery, Wiegering and colleagues find a way of inhibiting translation of MYC in colorectal cancer cells by directly targeting the translation initiation factor eIF4A, resulting in inhibition of MYC-dependent proliferation of colorectal tumor cells in vitro and in vivo. |
