| First Author | Zhang Z | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 23 | Pages | 3671-8 |
| PubMed ID | 26474644 | Mgi Jnum | J:227760 |
| Mgi Id | MGI:5702780 | Doi | 10.1016/j.febslet.2015.09.032 |
| Citation | Zhang Z, et al. (2015) MiR-455-3p regulates early chondrogenic differentiation via inhibiting Runx2. FEBS Lett 589(23):3671-8 |
| abstractText | The expression of miR-455-3p has been shown to be up-regulated in chondrogenesis of mesenchymal stem cell, but its role in different stages during chondrogenesis remains unknown. Here, we show that miR-455-3p is increased in ATDC5 cells from 0d to 21d, but rapidly decreases at 28d, and a similar expression kinetic is detected in the development of mouse embryos. We show that miR-455-3p functions as an activator for early chondrogenic differentiation, most likely by inhibiting the expression of Runt-related transcription factor 2 (Runx2) as indicated by luciferase reporter assays. In conclusion, miR-455-3p may activate early chondrogenesis by directly targeting Runx2. |
