| First Author | Ji X | Year | 2015 |
| Journal | FEBS Lett | Volume | 589 |
| Issue | 24 Pt B | Pages | 3938-44 |
| PubMed ID | 26592151 | Mgi Jnum | J:228141 |
| Mgi Id | MGI:5705429 | Doi | 10.1016/j.febslet.2015.11.029 |
| Citation | Ji X, et al. (2015) Cystatin C attenuates insulin signaling transduction by promoting endoplasmic reticulum stress in hepatocytes. FEBS Lett 589(24 Pt B):3938-44 |
| abstractText | It has been reported that cystatin c (Cys C) closely correlates with metabolic disorders such as obesity and diabetes. However, it is still unknown whether Cys C plays a role for these disorders. Our results showed that the insulin signal transduction was largely impaired by Cys C in hepatocytes. In myotubes, however, the insulin signal transduction was not affected. Following experiments revealed that Cys C could induce endoplasmic reticulum stress (ER stress) in hepatocytes, whereas Cys C had no such an effect in myotubes. The alleviation of ER stress by 4-Phenyl butyric acid (4-PBA) restored the impaired insulin signal transduction in Cys C-treated hepatocytes. These results provided direct evidence that, by inducing ER stress, Cys C impairs insulin signal transduction in hepatocytes. |
