| First Author | Shen L | Year | 2016 |
| Journal | Gene | Volume | 575 |
| Issue | 2 Pt 3 | Pages | 761-4 |
| PubMed ID | 26415879 | Mgi Jnum | J:228524 |
| Mgi Id | MGI:5707549 | Doi | 10.1016/j.gene.2015.09.060 |
| Citation | Shen L, et al. (2016) MicroRNA-23a regulates 3T3-L1 adipocyte differentiation. Gene 575(2 Pt 3):761-4 |
| abstractText | MicroRNAs (miRNAs) are small, non-coding RNAs, which are involved in regulation of a variety of biological processes. Since previous studies regarding the role of miRNAs in the regulation of adipogenic differentiation have shown that miRNA-27a, one member of miRNA-23a approximately 27a approximately 24 cluster, could suppress adipogenesis. We now investigated whether miRNA-23a regulates adipogenic differentiation. In the present study, we showed that the expression of miRNA-23a is decreased during the process of adipogenic differentiation. Over-expression of miRNA-23a decreased lipid accumulation and triglyceride content in 3T3-L1 adipocytes. Our results also demonstrated that miRNA-23a decreases mRNA levels of adipocyte-specific genes involved in lipogenic transcription, fatty acid synthesis and fatty acid transport. These findings suggested miRNA-23a to be a new type of adipogenic depressor and to play an important role in regulating adipocyte differentiation. |
