| First Author | Cui Y | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 1 | Pages | 185-92 |
| PubMed ID | 26763102 | Mgi Jnum | J:229916 |
| Mgi Id | MGI:5754894 | Doi | 10.1002/1873-3468.12024 |
| Citation | Cui Y, et al. (2016) Exosomes derived from mineralizing osteoblasts promote ST2 cell osteogenic differentiation by alteration of microRNA expression. FEBS Lett 590(1):185-92 |
| abstractText | Mineralizing osteoblasts (MOBs) can release exosomes, although the functional significance remains unclear. In the present study, we demonstrate that exosomes derived from mineralizing pre-osteoblast MC3T3-E1 cells can promote bone marrow stromal cell (ST2) differentiation to osteoblasts. We reveal that MOB-derived exosomes significantly influence miRNA profiles in recipient ST2 cells, and these changes tend to activate the Wnt signaling pathway by inhibiting Axin1 expression and increasing beta-catenin expression. We also suggest that MOB derived-exosomes partly induce the variation in miRNA expression in recipient ST2 cells by exosomal miRNA transfer. These findings suggest an exosome-mediated mode of cell-to-cell communication in the osteogenic microenvironment, and also indicate the potential of MOB exosomes in bone tissue engineering. |
