| First Author | Lee JK | Year | 2016 |
| Journal | Cancer Cell | Volume | 29 |
| Issue | 4 | Pages | 536-547 |
| PubMed ID | 27050099 | Mgi Jnum | J:231826 |
| Mgi Id | MGI:5775229 | Doi | 10.1016/j.ccell.2016.03.001 |
| Citation | Lee JK, et al. (2016) N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells. Cancer Cell 29(4):536-47 |
| abstractText | MYCN amplification and overexpression are common in neuroendocrine prostate cancer (NEPC). However, the impact of aberrant N-Myc expression in prostate tumorigenesis and the cellular origin of NEPC have not been established. We define N-Myc and activated AKT1 as oncogenic components sufficient to transform human prostate epithelial cells to prostate adenocarcinoma and NEPC with phenotypic and molecular features of aggressive, late-stage human disease. We directly show that prostate adenocarcinoma and NEPC can arise from a common epithelial clone. Further, N-Myc is required for tumor maintenance, and destabilization of N-Myc through Aurora A kinase inhibition reduces tumor burden. Our findings establish N-Myc as a driver of NEPC and a target for therapeutic intervention. |
