| First Author | Bando M | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 7 | Pages | 992-1001 |
| PubMed ID | 26991015 | Mgi Jnum | J:232138 |
| Mgi Id | MGI:5776092 | Doi | 10.1002/1873-3468.12132 |
| Citation | Bando M, et al. (2016) High incorporation of long-chain fatty acids contributes to the efficient production of acylated ghrelin in ghrelin-producing cells. FEBS Lett 590(7):992-1001 |
| abstractText | The mechanisms for supplying octanoic acid for ghrelin acylation in X/A-like cells are incompletely understood. We found that long-chain fatty acids were incorporated at a higher rate in the ghrelin-producing cell line MGN3-1 than in MIN6 cells, in part due to higher expression level of long-chain fatty acyl-CoA synthetase family member 1 (Acsl1). Inhibition of ACSLs by triacsin C profoundly suppressed acylated ghrelin production. These results suggest that high incorporation of long-chain fatty acids into the ghrelin-producing cells plays a role in the supply of octanoic acid for ghrelin acylation. |
