| First Author | Zhang ZX | Year | 2015 |
| Journal | Biochem Biophys Res Commun | Volume | 465 |
| Issue | 2 | Pages | 225-31 |
| PubMed ID | 26248136 | Mgi Jnum | J:232891 |
| Mgi Id | MGI:5780385 | Doi | 10.1016/j.bbrc.2015.07.158 |
| Citation | Zhang ZX, et al. (2015) BRAF activated non-coding RNA (BANCR) promoting gastric cancer cells proliferation via regulation of NF-kappaB1. Biochem Biophys Res Commun 465(2):225-31 |
| abstractText | BACKGROUND AND OBJECTIVE: Long non-coding RNA, BANCR, has been demonstrated to contribute to the proliferation and migration of tumors. However, its molecular mechanism underlying gastric cancer is still unknown. In present study, we investigated whether BANCR was involved in the development of gastric cancer cells via regulation of NF-kappaB1. METHODS: Human gastric cancer tissues were isolated as well as human gastric cell lines MGC803 and BGC823 were cultured to investigate the role of BANCR in gastric cancer. RESULTS: BANCR expression was significantly up-regulated in gastric tumor tissues and gastric cell lines. Down-regulation of BANCR inhibited gastric cancer cell growth and promoted cell apoptosis, and it also contributed to a significant decrease of NF-kappaB1 (P50/105) expression and 3'UTR of NF-kappaB1 activity. Overexpression of NF-kappaB1 reversed the effect of BANCR on cancer cell growth and apoptosis. MiroRNA-9 (miR-9) targeted NF-kappaB1, and miR-9 inhibitor also reversed the effects of BANCR on gastric cancer cell growth and apoptosis. CONCLUSION: BANCR was highly expressed both in gastric tumor tissues and in cancer cells. NF-kappaB1 and miR-9 were involved in the role of BANCR in gastric cancer cell growth and apoptosis. |
