| First Author | Ye S | Year | 2016 |
| Journal | J Cell Sci | Volume | 129 |
| Issue | 2 | Pages | 269-76 |
| PubMed ID | 26598557 | Mgi Jnum | J:234688 |
| Mgi Id | MGI:5790570 | Doi | 10.1242/jcs.177675 |
| Citation | Ye S, et al. (2016) Wnt/beta-catenin and LIF-Stat3 signaling pathways converge on Sp5 to promote mouse embryonic stem cell self-renewal. J Cell Sci 129(2):269-76 |
| abstractText | Activation of leukemia inhibitor factor (LIF)-Stat3 or Wnt/beta-catenin signaling promotes mouse embryonic stem cell (mESC) self-renewal. A myriad of downstream targets have been identified in the individual signal pathways, but their common targets remain largely elusive. In this study, we found that the LIF-Stat3 and Wnt/beta-catenin signaling pathways converge on Sp5 to promote mESC self-renewal. Forced Sp5 expression can reproduce partial effects of Wnt/beta-catenin signaling but mimics most features of LIF-Stat3 signaling to maintain undifferentiated mESCs. Moreover, Sp5 is able to convert mouse epiblast stem cells into a naive pluripotent state. Thus, Sp5 is an important component of the regulatory network governing mESC naive pluripotency. |
