First Author | Penard-Lacronique V | Year | 2016 |
Journal | Cancer Cell | Volume | 30 |
Issue | 2 | Pages | 192-194 |
PubMed ID | 27505668 | Mgi Jnum | J:234908 |
Mgi Id | MGI:5792429 | Doi | 10.1016/j.ccell.2016.07.008 |
Citation | Penard-Lacronique V, et al. (2016) IDH1, Histone Methylation, and So Forth. Cancer Cell 30(2):192-4 |
abstractText | IDH mutants cause aberrant DNA and histone methylation and contribute to hematological and neuronal malignancies. In this issue of Cancer Cell, Inoue et al. describe a potential specific effect of IDH1 mutations that reduces Atm expression via inhibition of H3K9 demethylases, which may represent a first step toward cellular transformation. |