| First Author | Romagnoli PA | Year | 2016 |
| Journal | Proc Natl Acad Sci U S A | Volume | 113 |
| Issue | 30 | Pages | 8502-7 |
| PubMed ID | 27402748 | Mgi Jnum | J:235056 |
| Mgi Id | MGI:5792736 | Doi | 10.1073/pnas.1600713113 |
| Citation | Romagnoli PA, et al. (2016) IL-17A-producing resident memory gammadelta T cells orchestrate the innate immune response to secondary oral Listeria monocytogenes infection. Proc Natl Acad Sci U S A 113(30):8502-7 |
| abstractText | Memory gammadelta T cells are important for the clearance of Listeria monocytogenes infection in the intestinal mucosa. However, the mechanisms by which memory gammadelta T cells provide protection against secondary oral infection are poorly understood. Here we used a recombinant strain of L. monocytogenes that efficiently invades the intestinal epithelium to show that Vgamma4(+) memory gammadelta T cells represent a resident memory (Trm) population in the mesenteric lymph nodes (MLNs). The gammadelta Trm exhibited a remarkably static pattern of migration that radically changed following secondary oral L. monocytogenes infection. The gammadelta Trms produced IL-17A early after rechallenge and formed organized clusters with myeloid cells surrounding L. monocytogenes replication foci only after a secondary oral infection. Antibody blocking studies showed that in addition to IL-17A, the chemokine receptor C-X-C chemokine receptor 3 (CXCR3) is also important to enable the local redistribution of gammadelta Trm cells and myeloid cells specifically near the sites of L. monocytogenes replication within the MLN to restrict bacterial growth and spread. Our findings support a role for gammadelta Trms in orchestrating protective immune responses against intestinal pathogens. |
