| First Author | Liu YF | Year | 2016 |
| Journal | FEBS Lett | Volume | 590 |
| Issue | 16 | Pages | 2594-602 |
| PubMed ID | 27416888 | Mgi Jnum | J:235149 |
| Mgi Id | MGI:5792990 | Doi | 10.1002/1873-3468.12304 |
| Citation | Liu YF, et al. (2016) Progesterone induces the expression of lipocalin-2 through Akt-c-Myc pathway during mouse decidualization. FEBS Lett 590(16):2594-602 |
| abstractText | Lipocalin-2 (Lcn2) is a small glycoprotein involved in a number of biological processes such as inflammation and antibacterial response. In our study, Lcn2 is expressed in the subluminal stromal cells at implantation site on day 5 of pregnancy. The expression of Lcn2 in stromal cells is under the control of progesterone through Akt-c-Myc signaling pathway. Data from Lcn2 knockdown and recombinant protein treatments indicate that Lcn2 promotes mPGES-1 expression in stromal cells. The expression of Lcn2 and mPGES-1 is strongly stimulated by lipopolysaccharide (LPS), indicating that Lcn2 mediates LPS-induced inflammation. These findings shed light on the role of Lcn2 during decidualization. |
