| First Author | Merga YJ | Year | 2016 |
| Journal | Am J Physiol Gastrointest Liver Physiol | Volume | 310 |
| Issue | 11 | Pages | G1081-90 |
| PubMed ID | 27102559 | Mgi Jnum | J:235168 |
| Mgi Id | MGI:5793009 | Doi | 10.1152/ajpgi.00026.2016 |
| Citation | Merga YJ, et al. (2016) Importance of the alternative NF-kappaB activation pathway in inflammation-associated gastrointestinal carcinogenesis. Am J Physiol Gastrointest Liver Physiol 310(11):G1081-90 |
| abstractText | Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett's esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-kappaB signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-kappaB signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-kappaB signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development. |
