| First Author | Virós A | Year | 2016 |
| Journal | Cancer Discov | Volume | 6 |
| Issue | 6 | Pages | 581-3 |
| PubMed ID | 27261482 | Mgi Jnum | J:236808 |
| Mgi Id | MGI:5807308 | Doi | 10.1158/2159-8290.CD-16-0503 |
| Citation | Viros A, et al. (2016) So You Can Teach Old Fibroblasts New Tricks. Cancer Discov 6(6):581-3 |
| abstractText | New data show that as dermal fibroblasts grow old, they increase their secretion of the WNT antagonist sFRP2 to drive melanoma cell metastasis. sFRP2 suppresses beta-catenin and MITF signaling in melanoma cells, downregulating the redox regulator APE1, making melanoma cells more sensitive to oxidative stress and driving resistance to BRAF inhibitors. Thus, the aging microenvironment in elderly patient skin activates a signaling pathway that drives more aggressive melanoma cell behavior. Cancer Discov; 6(6); 581-3. (c)2016 AACR. |
