| First Author | Park SS | Year | 2016 |
| Journal | Mol Cell Endocrinol | Volume | 423 |
| Pages | 22-9 | PubMed ID | 26762765 |
| Mgi Jnum | J:237319 | Mgi Id | MGI:5811977 |
| Doi | 10.1016/j.mce.2015.12.023 | Citation | Park SS, et al. (2016) CREB/GSK-3beta signaling pathway regulates the expression of TR4 orphan nuclear receptor gene. Mol Cell Endocrinol 423:22-9 |
| abstractText | In this study, we show that reduction of glucose concentration increases TR4 expression in 3T3-L1 cells via stimulation of the GSK-3beta-CREB pathway. While GSK-3beta and CREB increased TR4 expression in 3T3-L1 cells, inhibition of CREB expression or activity resulted in loss of GSK-3beta-mediated enhancement of TR4 expression. In addition, CREB enhanced murine TR4 promoter activity via direct binding to a cAMP response element located in the promoter, and this CREB effect was further strengthened by GSK-3beta. Moreover, silencing of TR4 expression by a gene-specific microRNA inhibited CREB-induced lipid accumulation in 3T3-L1 adipocytes, suggesting that TR4 could be a key mediator of CREB-induced lipogenesis. |
