| First Author | Doerflinger M | Year | 2015 |
| Journal | FEBS J | Volume | 282 |
| Issue | 6 | Pages | 1006-16 |
| PubMed ID | 25565426 | Mgi Jnum | J:237326 |
| Mgi Id | MGI:5811984 | Doi | 10.1111/febs.13190 |
| Citation | Doerflinger M, et al. (2015) BH3-only proteins: a 20-year stock-take. FEBS J 282(6):1006-16 |
| abstractText | BH3-only proteins are the sentinels of cellular stress, and their activation commits cells to apoptosis. Since the discovery of the first BH3-only protein BAD almost 20 years ago, at least seven more BH3-only proteins have been identified in mammals. They are regulated by a variety of environmental stimuli or by developmental cues, and play a crucial role in cellular homeostasis. Some are considered to be tumor suppressors, and also play a significant role in other pathologies. Their non-apoptotic functions are controversial, but there is broad consensus emerging regarding their role in apoptosis, which may help in designing better therapeutic agents for treating a variety of human diseases. |
