| First Author | Qian J | Year | 2016 |
| Journal | Stem Cells | Volume | 34 |
| Issue | 7 | Pages | 1947-56 |
| PubMed ID | 26866937 | Mgi Jnum | J:238120 |
| Mgi Id | MGI:5818125 | Doi | 10.1002/stem.2337 |
| Citation | Qian J, et al. (2016) Protective Role of Adipose-Derived Stem Cells in Staphylococcus aureus-Induced Lung Injury is Mediated by RegIIIgamma Secretion. Stem Cells 34(7):1947-56 |
| abstractText | Effective and specific therapeutic approaches are still needed for treating acute lung injury caused by severe pneumonia. Adipose-derived stem cells (ADSCs) are well-characterized adult stem cells that have antibacterial and anti-inflammatory effects. In this study, we evaluated the therapeutic effect of ADSCs on Staphylococcus aureus-induced acute lung injury in mice. Our results showed that intratracheal injection of ADSCs could attenuate the severity of lung inflammation, and reduce the bacterial load as well as mortality among infected mice. Our experiments also revealed that the secretion of regenerating islet-derived IIIgamma (RegIIIgamma) is responsible for the protective effect of ADSCs. Moreover, the expression of RegIIIgamma requires TLR2, MyD88, and JAK2/STAT3 activation. In conclusion, ADSCs exhibit a direct antimicrobial activity that is mediated primarily by the TLR2-MyD88-JAK2/STAT3-dependent secretion of RegIIIgamma. Stem Cells 2016;34:1947-1956. |
