| First Author | Tsuruyama T | Year | 2017 |
| Journal | Oncogene | Volume | 36 |
| Issue | 9 | Pages | 1169-1175 |
| PubMed ID | 27721401 | Mgi Jnum | J:239246 |
| Mgi Id | MGI:5828035 | Doi | 10.1038/onc.2016.285 |
| Citation | Tsuruyama T, et al. (2017) Hotspots of MLV integration in the hematopoietic tumor genome. Oncogene 36(9):1169-1175 |
| abstractText | Extensive research has been performed regarding the integration sites of murine leukemia retrovirus (MLV) for the identification of proto-oncogenes. To date, the overlap of mutations within specific oligonucleotides across different tumor genomes has been regarded as a rare event; however, a recent study of MLV integration into the oncogene Zfp521 suggested the existence of a hotspot oligonucleotide for MLV integration. In the current review, we discuss the hotspots of MLV integration into several genes: c-Myc, Stat5a and N-myc, as well as ZFP521, as examined in tumor genomes. From this, MLV integration convergence within specific oligonucleotides is not necessarily a rare event. This short review aims to promote re-consideration of MLV integration within the tumor genome, which involves both well-known and potentially newly identified and novel mechanisms and specifications. |
