First Author | Hardie DG | Year | 2017 |
Journal | Cancer Cell | Volume | 31 |
Issue | 2 | Pages | 163-165 |
PubMed ID | 28196589 | Mgi Jnum | J:239674 |
Mgi Id | MGI:5829490 | Doi | 10.1016/j.ccell.2017.01.010 |
Citation | Hardie DG (2017) An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-alpha2 for Degradation. Cancer Cell 31(2):163-165 |
abstractText | There has been controversy regarding the role of AMPK in cancer, some of which may be due to functional differences between isoforms. In this issue of Cancer Cell, Vila et al. report that UBE2O, a ubiquitin ligase overexpressed in some human cancers, specifically triggers the ubiquitination and degradation of AMPK-alpha2. |