| First Author | Li D | Year | 2016 |
| Journal | Biochem Biophys Res Commun | Volume | 481 |
| Issue | 1-2 | Pages | 132-138 |
| PubMed ID | 27818196 | Mgi Jnum | J:240981 |
| Mgi Id | MGI:5896900 | Doi | 10.1016/j.bbrc.2016.10.152 |
| Citation | Li D, et al. (2016) Distinct functions of PPARgamma isoforms in regulating adipocyte plasticity. Biochem Biophys Res Commun 481(1-2):132-138 |
| abstractText | A better understanding of the mechanisms underlying obesity and its comorbidities is key to designing new therapies and treatments. PPARgamma is a master regulator of adipocyte biology but the functions of its isoforms are poorly distinguished. Here we demonstrated that PPARgamma1 is preferentially expressed in catabolic fat depots while PPARgamma2 presents itself at a higher level in browning-resistant depots. PPARgamma2, but not PPARgamma1, responds to endogenous ligands to induce adipogenesis, and the isoforms regulate distinct sets of white and brown adipocyte genes. Moreover, PPARgamma1 negatively correlates while PPARgamma2 positively correlates with adiposity in human subcutaneous and visceral fat. These results together indicate that PPARgamma1 and PPARgamma2 have distinct functions in regulating adipocyte plasticity, and future research should take into account the binary roles of both isoforms in order to identify druggable gene targets and pathways relevant for treatment of metabolic disorders. |
