| First Author | Zhang Y | Year | 2024 |
| Journal | EMBO J | Volume | 43 |
| Issue | 21 | Pages | 5114-5140 |
| PubMed ID | 39300210 | Mgi Jnum | J:358018 |
| Mgi Id | MGI:7779525 | Doi | 10.1038/s44318-024-00218-x |
| Citation | Zhang Y, et al. (2024) Astrocyte allocation during brain development is controlled by Tcf4-mediated fate restriction. EMBO J 43(21):5114-5140 |
| abstractText | Astrocytes in the brain exhibit regional heterogeneity contributing to regional circuits involved in higher-order brain functions, yet the mechanisms controlling their distribution remain unclear. Here, we show that the precise allocation of astrocytes to specific brain regions during development is achieved through transcription factor 4 (Tcf4)-mediated fate restriction based on their embryonic origin. Loss of Tcf4 in ventral telencephalic neural progenitor cells alters the fate of oligodendrocyte precursor cells to transient intermediate astrocyte precursor cells, resulting in mislocalized astrocytes in the dorsal neocortex. These ectopic astrocytes engage with neocortical neurons and acquire features reminiscent of dorsal neocortical astrocytes. Furthermore, Tcf4 functions as a suppressor of astrocyte fate during the differentiation of oligodendrocyte precursor cells derived from the ventral telencephalon, thereby restricting the fate to the oligodendrocyte lineage in the dorsal neocortex. Together, our findings highlight a previously unappreciated role for Tcf4 in regulating astrocyte allocation, offering additional insights into the mechanisms underlying neurodevelopmental disorders linked to Tcf4 mutations. |
