| First Author | Shi G | Year | 2017 |
| Journal | Gene | Volume | 612 |
| Pages | 25-28 | PubMed ID | 27697617 |
| Mgi Jnum | J:242096 | Mgi Id | MGI:5904409 |
| Doi | 10.1016/j.gene.2016.09.046 | Citation | Shi G, et al. (2017) Alcohol-associated cancer and deregulation of Pol III genes. Gene 612:25-28 |
| abstractText | Emerging evidence indicates that alcohol intake is associated with human cancers in different organs. However, the molecular mechanism of alcohol-associated human cancers remains to be elucidated. Here, this paper aimed to clarify a novel mechanism of alcohol-promoted cell transformation and tumor development. Alcohol induces JNK1 activation and increases cellular levels of c-Jun to upregulate Brf1 expression and Pol III gene transcription, leading to an enhancement of rates of cell transformation and tumor formation. |
