| First Author | Aoki H | Year | 2017 |
| Journal | FEBS Lett | Volume | 591 |
| Issue | 14 | Pages | 2121-2130 |
| PubMed ID | 28649756 | Mgi Jnum | J:243977 |
| Mgi Id | MGI:5912756 | Doi | 10.1002/1873-3468.12731 |
| Citation | Aoki H, et al. (2017) Lacto-ghrestatin, a novel bovine milk-derived peptide, suppresses ghrelin secretion. FEBS Lett 591(14):2121-2130 |
| abstractText | Ghrelin, an endogenous peptide isolated from the stomach, is known to stimulate food intake after peripheral administration. We found that the enzymatic digest of beta-lactoglobulin decreases ghrelin secretion from the ghrelin-producing cell line MGN3-1. The peptides present in the digest were comprehensively analyzed using the nanoLC-OrbitrapMS. Among them, we identified that the nonapeptide LIVTQTMKG, corresponding to beta-lactoglobulin(1-9), suppresses ghrelin secretion from MGN3-1 cells. We named LIVTQTMKG 'lacto-ghrestatin'. We found that lacto-ghrestatin decreases intracellular cAMP levels and mRNA expression levels of ghrelin production-related genes in MGN3-1 cells. Orally administered lacto-ghrestatin decreases plasma ghrelin levels and food intake in fasted mice. Lacto-ghrestatin is the first food-derived peptide to suppress ghrelin secretion in vitro and in vivo. |
