| First Author | Pavic K | Year | 2015 |
| Journal | FEBS J | Volume | 282 |
| Issue | 10 | Pages | 1871-90 |
| PubMed ID | 25757426 | Mgi Jnum | J:242888 |
| Mgi Id | MGI:5906993 | Doi | 10.1111/febs.13263 |
| Citation | Pavic K, et al. (2015) VHR/DUSP3 phosphatase: structure, function and regulation. FEBS J 282(10):1871-90 |
| abstractText | Vaccinia H1-related (VHR) phosphatase, also known as dual-specificity phosphatase (DUSP) 3, is a small member of the DUSP (also called DSP) family of phosphatases. VHR has a preference for phospho-tyrosine substrates, and has important roles in cellular signaling ranging from cell-cycle regulation and the DNA damage response to MAPK signaling, platelet activation and angiogenesis. VHR/DUSP3 has been implicated in several human cancers, where its tumor-suppressing and -promoting properties have been described. We give a detailed overview of VHR/DUSP3 phosphatase and compare it with its most closely related phosphatases DUSP13B, DUSP26 and DUSP27. |
