| First Author | Dang H | Year | 2017 |
| Journal | Cancer Cell | Volume | 32 |
| Issue | 1 | Pages | 101-114.e8 |
| PubMed ID | 28697339 | Mgi Jnum | J:243264 |
| Mgi Id | MGI:5908033 | Doi | 10.1016/j.ccell.2017.06.002 |
| Citation | Dang H, et al. (2017) Oncogenic Activation of the RNA Binding Protein NELFE and MYC Signaling in Hepatocellular Carcinoma. Cancer Cell 32(1):101-114.e8 |
| abstractText | Global transcriptomic imbalance is a ubiquitous feature associated with cancer, including hepatocellular carcinoma (HCC). Analyses of 1,225 clinical HCC samples revealed that a large numbers of RNA binding proteins (RBPs) are dysregulated and that RBP dysregulation is associated with poor prognosis. We further identified that oncogenic activation of a top candidate RBP, negative elongation factor E (NELFE), via somatic copy-number alterations enhanced MYC signaling and promoted HCC progression. Interestingly, NELFE induces a unique tumor transcriptome by selectively regulating MYC-associated genes. Thus, our results revealed NELFE as an oncogenic protein that may contribute to transcriptome imbalance in HCC through the regulation of MYC signaling. |
