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Publication : Prevalence of sexual dimorphism in mammalian phenotypic traits.

First Author  Karp NA Year  2017
Journal  Nat Commun Volume  8
Pages  15475 PubMed ID  28650954
Mgi Jnum  J:246057 Mgi Id  MGI:5920168
Doi  10.1038/ncomms15475 Citation  Karp NA, et al. (2017) Prevalence of sexual dimorphism in mammalian phenotypic traits. Nat Commun 8:15475
abstractText  The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans.
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