| First Author | Christakos S | Year | 2017 |
| Journal | J Biol Chem | Volume | 292 |
| Issue | 42 | Pages | 17559-17560 |
| PubMed ID | 29055009 | Mgi Jnum | J:248501 |
| Mgi Id | MGI:5920817 | Doi | 10.1074/jbc.H117.806901 |
| Citation | Christakos S (2017) In search of regulatory circuits that control the biological activity of vitamin D. J Biol Chem 292(42):17559-17560 |
| abstractText | Although the cytochrome P450 CYP27B1 plays a critical role in vitamin D biology, the molecular mechanisms involved in regulation of CYP27B1 have remained undefined. A new study has identified a kidney-specific control module distal to the Cyp27b1 gene that mediates the basal activity and hormonal regulation of Cyp27b1 This work provides a novel mechanism indicating differential regulation of Cyp27b1 in renal and non-renal cells and has implications for vitamin D biology in multiple sclerosis and perhaps other autoimmune diseases as well. |
