| First Author | Wang J | Year | 2016 |
| Journal | FEBS J | Volume | 283 |
| Issue | 9 | Pages | 1631-5 |
| PubMed ID | 26676765 | Mgi Jnum | J:248778 |
| Mgi Id | MGI:6093089 | Doi | 10.1111/febs.13628 |
| Citation | Wang J, et al. (2016) Structure of the mouse Toll-like receptor 13 ectodomain in complex with a conserved sequence from bacterial 23S ribosomal RNA. FEBS J 283(9):1631-5 |
| abstractText | Toll-like receptor 13 (TLR13) recognizes a conserved 10-nucleotide sequence from bacterial 23S ribosomal RNA, and binding of TLR13 to the target rRNA molecule triggers immune responses. Recently, the crystal structure of the TLR13 ectodomain bound by a 13-nucleotide single-stranded RNA (ssRNA13) was determined by using the initial phases provided by a cryo-electron microscopy map of TLR13 in complex with a 25-nucleotide ssRNA (ssRNA25). This structural snapshot describes a unique method for solving the crystal structure of the TLR13-ssRNA13 complex based on medium-resolution reconstruction of TLR13-ssRNA25 cryo-electron microscopy images. |
