| First Author | Taylor S | Year | 2017 |
| Journal | J Exp Med | Volume | 214 |
| Issue | 6 | Pages | 1663-1678 |
| PubMed ID | 28490441 | Mgi Jnum | J:249056 |
| Mgi Id | MGI:6093132 | Doi | 10.1084/jem.20161653 |
| Citation | Taylor S, et al. (2017) PD-1 regulates KLRG1(+) group 2 innate lymphoid cells. J Exp Med 214(6):1663-1678 |
| abstractText | Group 2 innate lymphoid cells (ILC-2s) regulate immune responses to pathogens and maintain tissue homeostasis in response to cytokines. Positive regulation of ILC-2s through ICOS has been recently elucidated. We demonstrate here that PD-1 is an important negative regulator of KLRG1(+) ILC-2 function in both mice and humans. Increase in KLRG1(+) ILC-2 cell numbers was attributed to an intrinsic defect in PD-1 signaling, which resulted in enhanced STAT5 activation. During Nippostrongylus brasiliensis infection, a significant expansion of KLRG1(+) ILC-2 subsets occurred in Pdcd1(-/-) mice and, upon adoptive transfer, Pdcd1(-/-) KLRG1(+) ILC-2s significantly reduced worm burden. Furthermore, blocking PD-1 with an antibody increased KLRG1(+) ILC-2 cell number and reduced disease burden. Therefore, PD-1 is required for maintaining the number, and hence function, of KLRG1(+) ILC-2s. |
