| First Author | Zhang Y | Year | 2017 |
| Journal | Nature | Volume | 548 |
| Issue | 7665 | Pages | 52-57 |
| PubMed ID | 28746310 | Mgi Jnum | J:253143 |
| Mgi Id | MGI:6095044 | Doi | 10.1038/nature23282 |
| Citation | Zhang Y, et al. (2017) Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature 548(7665):52-57 |
| abstractText | It has been proposed that the hypothalamus helps to control ageing, but the mechanisms responsible remain unclear. Here we develop several mouse models in which hypothalamic stem/progenitor cells that co-express Sox2 and Bmi1 are ablated, as we observed that ageing in mice started with a substantial loss of these hypothalamic cells. Each mouse model consistently displayed acceleration of ageing-like physiological changes or a shortened lifespan. Conversely, ageing retardation and lifespan extension were achieved in mid-aged mice that were locally implanted with healthy hypothalamic stem/progenitor cells that had been genetically engineered to survive in the ageing-related hypothalamic inflammatory microenvironment. Mechanistically, hypothalamic stem/progenitor cells contributed greatly to exosomal microRNAs (miRNAs) in the cerebrospinal fluid, and these exosomal miRNAs declined during ageing, whereas central treatment with healthy hypothalamic stem/progenitor cell-secreted exosomes led to the slowing of ageing. In conclusion, ageing speed is substantially controlled by hypothalamic stem cells, partially through the release of exosomal miRNAs. |
