| First Author | Takahashi H | Year | 2017 |
| Journal | Biochem Biophys Res Commun | Volume | 493 |
| Issue | 1 | Pages | 108-114 |
| PubMed ID | 28919422 | Mgi Jnum | J:250981 |
| Mgi Id | MGI:6103221 | Doi | 10.1016/j.bbrc.2017.09.067 |
| Citation | Takahashi H, et al. (2017) Over-expression of PPARalpha in obese mice adipose tissue improves insulin sensitivity. Biochem Biophys Res Commun 493(1):108-114 |
| abstractText | Peroxisome proliferator-activated receptor alpha (PPARalpha) is important in the regulation of lipid metabolism and expressed at high levels in the liver. Although PPARalpha is also expressed in adipose tissue, little is known about the relationship between its activation and the regulation of glucose metabolism. In this study, we developed adipose tissue specific PPARalpha over-expression (OE) mice. Metabolomics and insulin tolerance tests showed that OE induces branched-chain amino acid (BCAA) profile and improvement of insulin sensitivity. Furthermore, LC-MS and PCR analyses revealed that OE changes free fatty acid (FFA) profile and reduces obesity-induced inflammation. These findings suggested that PPARalpha activation in adipose tissue contributes to the improvement of glucose metabolism disorders via the enhancement of BCAA and FFA metabolism. |
