| First Author | Xia P | Year | 2017 |
| Journal | Biochem Biophys Res Commun | Volume | 490 |
| Issue | 2 | Pages | 111-116 |
| PubMed ID | 28571739 | Mgi Jnum | J:254006 |
| Mgi Id | MGI:6103669 | Doi | 10.1016/j.bbrc.2017.05.166 |
| Citation | Xia P, et al. (2017) Amelioration of adjuvant-induced arthritis in CCDC134-overexpressing transgenic mice. Biochem Biophys Res Commun 490(2):111-116 |
| abstractText | CCDC134 might be an immune cytokine and plays important and complex roles in the process in vivo. It was proved to illustrate its potent antitumor effects by augmenting CD8(+) T-cell-mediated immunity, but its role in the development of rheumatoid arthritis (RA) remains unclear. In this study, we demonstrated that development of adjuvant-induced arthritis and pro-inflammatory responses were more ameliorated in CCDC134-overexpressing transgenic mice than those in WT mice. The underlying mechanism of CCDC134-induced effects involved inhibition of T helper (Th) 1 and Th17 cell differentiation. These findings indicate that overexpression of CCDC134 exerts potent anti-inflammatory effects through selective modulation of pathogenic Th1 and Th17 cells, and might provide insights into the role of CCDC134 as a unique therapeutic agent for the treatment of rheumatoid arthritis. |
