| First Author | De La Fuente AG | Year | 2017 |
| Journal | Cell Rep | Volume | 20 |
| Issue | 8 | Pages | 1755-1764 |
| PubMed ID | 28834740 | Mgi Jnum | J:254833 |
| Mgi Id | MGI:6103929 | Doi | 10.1016/j.celrep.2017.08.007 |
| Citation | De La Fuente AG, et al. (2017) Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination. Cell Rep 20(8):1755-1764 |
| abstractText | The role of the neurovascular niche in CNS myelin regeneration is incompletely understood. Here, we show that, upon demyelination, CNS-resident pericytes (PCs) proliferate, and parenchymal non-vessel-associated PC-like cells (PLCs) rapidly develop. During remyelination, mature oligodendrocytes were found in close proximity to PCs. In Pdgfb(ret/ret) mice, which have reduced PC numbers, oligodendrocyte progenitor cell (OPC) differentiation was delayed, although remyelination proceeded to completion. PC-conditioned medium accelerated and enhanced OPC differentiation in vitro and increased the rate of remyelination in an ex vivo cerebellar slice model of demyelination. We identified Lama2 as a PC-derived factor that promotes OPC differentiation. Thus, the functional role of PCs is not restricted to vascular homeostasis but includes the modulation of adult CNS progenitor cells involved in regeneration. |
