| First Author | Singha AK | Year | 2017 |
| Journal | Cytokine | Volume | 91 |
| Pages | 89-95 | PubMed ID | 28039843 |
| Mgi Jnum | J:253305 | Mgi Id | MGI:6109317 |
| Doi | 10.1016/j.cyto.2016.12.009 | Citation | Singha AK, et al. (2017) IL-3 and GM-CSF modulate functions of splenic macrophages in ENU induced leukemia. Cytokine 91:89-95 |
| abstractText | Leukemia is often accompanied by enhanced susceptibility to infection due to compromised B cell and T cell functions. The alterations in macrophage functions in leukemia remain less investigated. Herein, we examined macrophages for their functions and responsiveness to IL-3 and GM-CSF in ENU-induced leukemia in BALB/c mice. We observed that the macrophages from the leukemic mice had less phagocytic activity, reduced chemotactic activity in response to monocyte chemoattractant protein-1(MCP-1), and decreased expression of iNOS, GM-CSF, TLR2, TLR4, IFN-gamma and TNF-alpha. These impaired macrophage functions in leukemic mice were significantly corrected by IL-3 and GM-CSF treatment indicating the therapeutic benefit of these two cytokines in leukemia. |
