| First Author | Kawamura Y | Year | 2017 |
| Journal | FEBS Lett | Volume | 591 |
| Issue | 22 | Pages | 3709-3720 |
| PubMed ID | 29029363 | Mgi Jnum | J:257508 |
| Mgi Id | MGI:6118024 | Doi | 10.1002/1873-3468.12881 |
| Citation | Kawamura Y, et al. (2017) Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain. FEBS Lett 591(22):3709-3720 |
| abstractText | Astrocytes, which support diverse neuronal functions, are generated from multipotent neural stem/precursor cells (NS/PCs) during brain development. Although many astrocyte-inducing factors have been identified and studied in vitro, the regions and/or cells that produce these factors in the developing brain remain elusive. Here, we show that meninges-produced factors induce astrocytic differentiation of NS/PCs. Consistent with the timing when astrocytic differentiation of NS/PCs increases, expression of astrocyte-inducing factors is upregulated. Meningeal secretion-mimicking combinatorial treatment of NS/PCs with bone morphogenetic protein 4, retinoic acid and leukemia inhibitory factor synergistically activate the promoter of a typical astrocytic marker, glial fibrillary acidic protein. Taken together, our data suggest that meninges play an important role in astrocytic differentiation of NS/PCs in the developing brain. |
