| First Author | Laforge M | Year | 2016 |
| Journal | Cell Death Differ | Volume | 23 |
| Issue | 1 | Pages | 89-98 |
| PubMed ID | 26024391 | Mgi Jnum | J:259867 |
| Mgi Id | MGI:6141629 | Doi | 10.1038/cdd.2015.42 |
| Citation | Laforge M, et al. (2016) NF-kappaB pathway controls mitochondrial dynamics. Cell Death Differ 23(1):89-98 |
| abstractText | The Optic atrophy 1 protein (OPA1) is a key element in the dynamics and morphology of mitochondria. We demonstrated that the absence of IkappaB kinase-alpha, which is a key element of the nonclassical NF-kappaB pathway, has an impact on the mitochondrial network morphology and OPA1 expression. In contrast, the absence of NF-kappaB essential modulator (NEMO) or IkappaB kinase-beta, both of which are essential for the canonical NF-kappaB pathway, has no impact on mitochondrial dynamics. Whereas Parkin has been reported to positively regulate the expression of OPA1 through NEMO, herein we found that PARK2 overexpression did not modify the expression of OPA1. PARK2 expression reduced the levels of Bax, and it prevented stress-induced cell death only in Bak-deficient mouse embryonic fibroblast cells. Collectively, our results point out a role of the nonclassical NF-kappaB pathway in the regulation of mitochondrial dynamics and OPA1 expression. |
