| First Author | Yousefzadeh MJ | Year | 2018 |
| Journal | Aging Cell | Volume | 17 |
| Issue | 2 | PubMed ID | 29290100 |
| Mgi Jnum | J:258522 | Mgi Id | MGI:6144358 |
| Doi | 10.1111/acel.12706 | Citation | Yousefzadeh MJ, et al. (2018) Circulating levels of monocyte chemoattractant protein-1 as a potential measure of biological age in mice and frailty in humans. Aging Cell 17(2) |
| abstractText | A serum biomarker of biological versus chronological age would have significant impact on clinical care. It could be used to identify individuals at risk of early-onset frailty or the multimorbidities associated with old age. It may also serve as a surrogate endpoint in clinical trials targeting mechanisms of aging. Here, we identified MCP-1/CCL2, a chemokine responsible for recruiting monocytes, as a potential biomarker of biological age. Circulating monocyte chemoattractant protein-1 (MCP-1) levels increased in an age-dependent manner in wild-type (WT) mice. That age-dependent increase was accelerated in Ercc1(-/Delta) and Bubr1(H/H) mouse models of progeria. Genetic and pharmacologic interventions that slow aging of Ercc1(-/Delta) and WT mice lowered serum MCP-1 levels significantly. Finally, in elderly humans with aortic stenosis, MCP-1 levels were significantly higher in frail individuals compared to nonfrail. These data support the conclusion that MCP-1 can be used as a measure of mammalian biological age that is responsive to interventions that extend healthy aging. |
