| First Author | Chang JS | Year | 2018 |
| Journal | PLoS One | Volume | 13 |
| Issue | 3 | Pages | e0195007 |
| PubMed ID | 29566074 | Mgi Jnum | J:260110 |
| Mgi Id | MGI:6148363 | Doi | 10.1371/journal.pone.0195007 |
| Citation | Chang JS, et al. (2018) A truncated PPAR gamma 2 localizes to mitochondria and regulates mitochondrial respiration in brown adipocytes. PLoS One 13(3):e0195007 |
| abstractText | Peroxisome proliferator-activated receptor gamma (PPARgamma) is a key regulator of brown adipocyte differentiation and thermogenesis. The PPARgamma gene produces two isoforms, PPARgamma1 and PPARgamma2. PPARgamma2 is identical to PPARgamma1 except for additional 30 amino acids present in the N-terminus of PPARgamma2. Here we report that the C-terminally truncated form of PPARgamma2 is predominantly present in the mitochondrial matrix of brown adipocytes and that it binds to the D-loop region of mitochondrial DNA (mtDNA), which contains the promoter for mitochondrial electron transport chain (ETC) genes. Expression of mitochondrially targeted MLS-PPARgamma2 in brown adipocytes increases mtDNA-encoded ETC gene expression concomitant with enhanced mitochondrial respiration. These results suggest that direct regulation of mitochondrially encoded ETC gene expression by mitochondrial PPARgamma2, in part, underlies the isoform-specific role for PPARgamma2 in brown adipocytes. |
