| First Author | Jia Y | Year | 2018 |
| Journal | Biochim Biophys Acta | Volume | 1864 |
| Issue | 3 | Pages | 784-792 |
| PubMed ID | 29277325 | Mgi Jnum | J:262159 |
| Mgi Id | MGI:6149304 | Doi | 10.1016/j.bbadis.2017.12.029 |
| Citation | Jia Y, et al. (2018) SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA. Biochim Biophys Acta 1864(3):784-792 |
| abstractText | Molecular mechanisms for macrophage immune responses modulated by SIRT1 during sepsis remain unclear. Here, we show that SIRT1 expression is down-regulated in macrophages from mouse sepsis model or LPS stimulation. SIRT1 expression in macrophages correlates with low levels of a long noncoding RNA (lncRNA)-NONMMUT003701 [named as lncRNA-CCL2]. SIRT1 inhibits lncRNA-CCL2 expression via sustaining a repressive chromatin state in the lncRNA-CCL2 locus. The inflammation cytokines expression is downregulated by knockdown of lncRNA-CCL2. Such inhibition can be reversed partly by decreased SIRT1 activity. Thus, this work uncovers previously unidentified mechanisms in which SIRT1 associates with lncRNA and lncRNA regulates macrophage inflammatory response. |
