| First Author | Hao J | Year | 2017 |
| Journal | Exp Cell Res | Volume | 357 |
| Issue | 2 | Pages | 155-162 |
| PubMed ID | 28501460 | Mgi Jnum | J:261610 |
| Mgi Id | MGI:6151487 | Doi | 10.1016/j.yexcr.2017.05.010 |
| Citation | Hao J, et al. (2017) Involvement of JNK signaling in IL4-induced M2 macrophage polarization. Exp Cell Res 357(2):155-162 |
| abstractText | It has been generally accepted that alternatively activated macrophages (M2), which can be induced by type 2 cytokines such as IL-4, is responsible for tissue repair. However, the function of JNK in IL-4-induced M2 macrophage polarization remains unclear. Here, we demonstrated that M0 macrophages can be polarized into M2 status in response to IL-4 stimulation with the increased expression of the M2-specific molecular markers. We also found that IL-4 induced higher expression of JNK and transcription factor c-Myc in M2 macrophages. Our Q-PCR and Western blot results showed that JNK increased the expression of c-Myc and M2 markers Arg1, Mrc1. We also demonstrated c-Myc was the downstream of IL-4-JNK pathway. Further, the depletion of c-Myc, Arg1 and Mrc1 could inhibit the migration ability of M2 macrophages. Taken together, our data establishes a new role for JNK signaling in IL-4-induced alternative activation of macrophages and may provide a novel strategy for immune therapy. |
