| First Author | Tilg H | Year | 2018 |
| Journal | Cancer Cell | Volume | 33 |
| Issue | 6 | Pages | 954-964 |
| PubMed ID | 29657127 | Mgi Jnum | J:262544 |
| Mgi Id | MGI:6162283 | Doi | 10.1016/j.ccell.2018.03.004 |
| Citation | Tilg H, et al. (2018) The Intestinal Microbiota in Colorectal Cancer. Cancer Cell 33(6):954-964 |
| abstractText | Experimental evidence from the past years highlights a key role for the intestinal microbiota in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on microbial composition and provides risk for developing colorectal carcinoma (CRC). Large metagenomic studies in human CRC associated microbiome signatures with the colorectal adenoma-carcinoma sequence, suggesting a fundamental role of the intestinal microbiota in the evolution of gastrointestinal malignancy. Basic science established a critical function for the intestinal microbiota in promoting tumorigenesis. Further studies are needed to decipher the mechanisms of tumor promotion and microbial co-evolution in CRC, which may be exploited therapeutically in the future. |
