| First Author | Virmani T | Year | 2003 |
| Journal | EMBO J | Volume | 22 |
| Issue | 20 | Pages | 5347-57 |
| PubMed ID | 14532108 | Mgi Jnum | J:263488 |
| Mgi Id | MGI:6189675 | Doi | 10.1093/emboj/cdg514 |
| Citation | Virmani T, et al. (2003) Synaptotagmin 7 splice variants differentially regulate synaptic vesicle recycling. EMBO J 22(20):5347-57 |
| abstractText | The speed of synaptic vesicle recycling determines the efficacy of neurotransmission during repetitive stimulation. Synaptotagmins are synaptic C(2)-domain proteins that are involved in exocytosis, but have also been linked to endocytosis. We now demonstrate that upon expression in transfected neurons, a short splice variant of synaptotagmin 7 that lacks C(2)-domains accelerates endocytic recycling of synaptic vesicles, whereas a longer splice variant that contains C(2)-domains decelerates recycling. These results suggest that alternative splicing of synaptotagmin 7 acts as a molecular switch, which targets vesicles to fast and slow recycling pathways. |
