| First Author | Rezende RM | Year | 2018 |
| Journal | Nat Commun | Volume | 9 |
| Issue | 1 | Pages | 3151 |
| PubMed ID | 30089795 | Mgi Jnum | J:266402 |
| Mgi Id | MGI:6209229 | Doi | 10.1038/s41467-018-05487-9 |
| Citation | Rezende RM, et al. (2018) gammadelta T cells control humoral immune response by inducing T follicular helper cell differentiation. Nat Commun 9(1):3151 |
| abstractText | gammadelta T cells have many known functions, including the regulation of antibody responses. However, how gammadelta T cells control humoral immunity remains elusive. Here we show that complete Freund's adjuvant (CFA), but not alum, immunization induces a subpopulation of CXCR5-expressing gammadelta T cells in the draining lymph nodes. TCRgammadelta(+)CXCR5(+) cells present antigens to, and induce CXCR5 on, CD4 T cells by releasing Wnt ligands to initiate the T follicular helper (Tfh) cell program. Accordingly, TCRdelta(-/-) mice have impaired germinal center formation, inefficient Tfh cell differentiation, and reduced serum levels of chicken ovalbumin (OVA)-specific antibodies after CFA/OVA immunization. In a mouse model of lupus, TCRdelta(-/-) mice develop milder glomerulonephritis, consistent with decreased serum levels of lupus-related autoantibodies, when compared with wild type mice. Thus, modulation of the gammadelta T cell-dependent humoral immune response may provide a novel therapy approach for the treatment of antibody-mediated autoimmunity. |
