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Publication : Evidence for acute contraction-induced myokine secretion by C2C12 myotubes.

First Author  Furuichi Y Year  2018
Journal  PLoS One Volume  13
Issue  10 Pages  e0206146
PubMed ID  30356272 Mgi Jnum  J:267716
Mgi Id  MGI:6258081 Doi  10.1371/journal.pone.0206146
Citation  Furuichi Y, et al. (2018) Evidence for acute contraction-induced myokine secretion by C2C12 myotubes. PLoS One 13(10):e0206146
abstractText  Skeletal muscle is considered a secretory organ that produces bioactive proteins known as myokines, which are released in response to various stimuli. However, no experimental evidence exists regarding the mechanism by which acute muscle contraction regulates myokine secretion. Here, we present evidence that acute contractions induced myokine secretion from C2C12 myotubes. Changes in the cell culture medium unexpectedly triggered the release of large amounts of proteins from the myotubes, and these proteins obscured the contraction-induced myokine secretion. Once protein release was abolished, the secretion of interleukin-6 (IL-6), the best-known regulatory myokine, increased in response to a 1-hour contraction evoked by electrical stimulation. Using this experimental condition, intracellular calcium flux, rather than the contraction itself, triggered contraction-induced IL-6 secretion. This is the first report to show an evidence for acute contraction-induced myokine secretion by skeletal muscle cells.
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